Tuesday, March 9, 2010

Australia Substantially Increases Research Collaboration with China, According to Thomson Reuters Study

New Zealand researchers double collaboration with Spain and Norway

PHILADELPHIA and LONDON, March 9 /CNW/ -- A study from Thomson Reuters released today shows broadening international collaboration in the research of Australia and, to a lesser degree, New Zealand, over the past 10 years. The United States continues to be the biggest contributor to Australian and New Zealand publications, but of special interest is a sizable increase of Australia's collaboration with China.
The study, Global Research Report: Australia and New Zealand, found that collaboration within the Asia Pacific region is notably changing. Though collaboration with Australia among some Asia Pacific nations (such as New Zealand, India, and Singapore) increased, and collaboration with China doubled (rising from 2.3 percent to 4.4 percent of all Australian outputs), collaboration with Japan remained unchanged. Likewise, Japan's rank as a contributor of co-authored papers with New Zealand fell from sixth to eighth. 

"Researchers in Australia and New Zealand have been increasing their share of publications co-authored with international colleagues," said Jonathan Adams, director of research evaluation at Thomson Reuters. "We've seen a shift in geographic focus of these collaborations. While such countries as Russia and South Africa decrease in importance, there are increases in collaboration with Spain and Switzerland, and more importantly, with China and India."

    Other key findings include:
    --  Australia's share of world research publication output has grown
        steadily from 2.85 percent in 1999 to 3.18 percent in 2008.
    --  In the same period, the volume of Australian publications has risen
        annually by an average of 5 percent -- a growth rate higher than that
        of world publication averages.
    --  Computer science, materials science, environment/ecology, and clinical
        medicine are subject areas where Australia has increased its outputs,
        consistent with its national research priorities.
    --  Subject areas that have grown in the volume of outputs in New Zealand
        are computer sciences, biology and biochemistry, immunology, and
        neurosciences and behavior, consistent with the country's government
        research, science and technology agenda.

The study is part of the Global Research Report series from Thomson Reuters that illustrates the changing landscape and dynamics of scientific research around the world and draws on data found in Web of Science(SM), available on the Thomson Reuters Web of Knowledge(SM), platform -- the world's largest citation environment of the highest quality scholarly literature.

For more information, please visit http://researchanalytics.thomsonreuters.com/grr/.

Monday, March 8, 2010

New studies showPCA3 prostate cancer marker can help guide repeat prostate biopsy decisions and predict risk of aggressive cancer

More than 2,400 men tested in largest worldwide studies to date.

QUEBEC CITY, March 8 /CNW Telbec/ - DiagnoCure, Inc. (TSX: CUR), a life sciences company commercializing high-value cancer diagnostic tests and delivering laboratory services, announced that the clinical utility of the PROGENSA(R) PCA3 test, developed and commercialized by its partner Gen-Probe (NASDAQ: GPRO), was confirmed in two large worldwide studies, conducted in a subset of patients in GlaxoSmithKline's REDUCE trial of dutasteride. The results demonstrate that PCA3 can help determine whether men suspected of having prostate cancer should undergo a repeat biopsy and can predict the risk of having an aggressive cancer. The studies were presented last week at the American Society of Clinical Oncology's Genitourinary Cancers Symposium (ASCO GU) in San Francisco

"This four-year multicenter worldwide study is the largest to date performed on DiagnoCure's PCA3 marker. It shows that the test can be useful in managing patients suspected of having prostate cancer. For doctors and patients struggling with the dilemma of the traditional PSA test that has a well-known low specificity, the PCA3 test, with a specificity of up to 80% (depending on the cut-off), can offer a more reliable answer. These results indicate that the PCA3 test can help reduce unnecessary prostate biopsies and help identify patients that have a more aggressive cancer, representing a step forward in personalized patient care," said Dr Yves Fradet, co-founder and President of DiagnoCure. 

In the studies presented at the ASCO GU meeting, PCA3 was used to test urine samples from men enrolled in the REDUCE trial of GlaxoSmithKline's drug dutasteride. PCA3 testing was done on urine samples from 1,140 men in the placebo arm of the REDUCE trial, and from 1,308 men treated with dutasteride. All men underwent prostate biopsies two and four years after enrollment in the study. 

The first PCA3 study presented at the meeting originated from the placebo arm of the REDUCE trial. This study, which was highlighted in ASCO's official press program, showed that PCA3 scores were significantly correlated with a positive prostate biopsy result, and that men who had higher PCA3 scores were more likely to have prostate cancer. Specifically, cancer was diagnosed in only 6% of men with very low PCA3 scores, but in 57% of men with very high PCA3 scores. 

PCA3 scores also correlated with cancer aggressiveness (as defined by the Gleason Score): median PCA3 scores were higher in men with high-grade cancers than in those with low-grade cancers. Finally, the PCA3 test also predicted the likelihood of a positive prostate biopsy performed two years after the test. 

The second PCA3 study originated from the patients treated with dutasteride in the REDUCE trial. This study demonstrated that PCA3 also can be used to predict prostate biopsy outcomes in men taking dutasteride. It confirmed earlier research that showed PCA3 outperforms serum PSA testing for prostate cancer detection, and improves diagnostic accuracy when combined with serum PSA testing and other clinical information.
About DiagnoCure 

DiagnoCure (TSX: CUR) is a life sciences company commercializing high-value cancer diagnostic tests and delivering laboratory services that increase clinician and patient confidence in making critical treatment decisions. DiagnoCure Oncology Laboratories, a subsidiary of DiagnoCure Inc., launched in 2008 the Previstage(TM) GCC Colorectal Cancer Staging Test, the first GCC-based molecular test for the management of colorectal cancer. A major study published in the February 18, 2009, edition of the Journal of the American Medical Association demonstrated that GCC, to which DiagnoCure owns exclusive worldwide diagnostic rights, is the strongest independent predictor of colorectal cancer recurrence. More clinical studies are underway to confirm the clinical utility of the Previstage(TM) GCC test. The Company has a strategic alliance with Gen-Probe (NASDAQ: GPRO) for the development and commercialization of a second-generation prostate cancer test using PCA3, DiagnoCure's proprietary molecular marker. This test is available through laboratories in the U.S. using PCA3 analyte specific reagents (ASR) from Gen-Probe, in Europe as the CE-marked PROGENSA(R) PCA3 in vitro assay, and in Canada. A clinical study aimed at securing FDA approval for the commercialization of PROGENSA(R) PCA3 test in the U.S. is underway. For more information, visit www.diagnocure.com.